Co-existence and Co-release of Gastrin 34 N-terminal Fragment with Gastrin 17 in Rat Stomach
نویسندگان
چکیده
منابع مشابه
Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
Cellular synthesis of peptide hormones requires PCs (prohormone convertases) for the endoproteolysis of prohormones. Antral G-cells synthesize the most gastrin and express PC1/3, 2 and 5/6 in the rat and human. But the cleavage sites in progastrin for each PC have not been determined. Therefore, in the present study, we measured the concentrations of progastrin, processing intermediates and alp...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1988
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.64.10_1065